Leadership
Visionaries bridging AI innovation and clinical excellence.
Biography
- Over 20 years’ experience in NLP and AI in both academic and industrial settings
- Hundreds of publications in high tier journals in EHRs, RWD medical informatics, NLP/AI innovation and translational research.
- Chief Scientist of IMO Health, CSO of Melax Technoliges, VP of Biopharma Solutions at GeneDx Mount Sinai Genomic Inc, where she led the development of clinical evidence generation platforms and clinical research in oncology, immunology, cardiovascular, respiratory, and rare diseases.
- Tenue-track faculty member and principal investigator at the University of Connecticut, UConn Health Center, Mount Sinai Health Systems and Tulane University bridging research, health services, and teaching.
Selected Publications
Lee, Kyeryoung et al. A4SLR: An Agentic AI-Assisted Systematic Literature Review Framework to Augment Evidence Synthesis for HEOR and HTA Value in Health, DOI: 10.1016/j.jval.2025.08.002
Fleurence, Rachael L. et al. ELEVATE-GenAI: Reporting Guidelines for the Use of Large Language Models in Health Economics and Outcomes Research: An ISPOR Working Group Report. Value in Health 10.1016/j.jval.2025.06.018
Fleurence RL, Bian J, Wang X, Xu H, Dawoud D, Higashi M, Chhatwal J; ISPOR Working Group on Generative AI. Generative Artificial Intelligence for Health Technology Assessment: Opportunities, Challenges, and Policy Considerations: An ISPOR Working Group Report. Value Health. 2025 Feb;28(2):175-183. doi: 10.1016/j.jval.2024.10.3846. Epub 2024 Nov 12. PMID: 39536966; PMCID: PMC11786987.
Fleurence RL, Wang X, Bian J, Higashi MK, Ayer T, Xu H, Dawoud D, Chhatwal J; ISPOR Working Group on Generative AI. A Taxonomy of Generative Artificial Intelligence in Health Economics and Outcomes Research: An ISPOR Working Group Report. Value Health. 2025 Nov;28(11):1601-1610. doi: 10.1016/j.jval.2025.04.2167. Epub 2025 May 8. PMID: 40348011.
Ying Li, Surabhi Datta, Majid Rastegar-Mojarad, Kyeryoung Lee, Hunki Paek, Julie Glasgow, Chris Liston, Long He, Xiaoyan Wang, Yingxin Xu, Enhancing systematic literature reviews with generative artificial intelligence: development, applications, and performance evaluation, Journal of the American Medical Informatics Association, 2025;, ocaf030, https://doi.org/10.1093/jamia/ocaf030
S Datta, K Lee, H Paek, MR Mojarad1 ∙ V Prabhu, J Zhang ∙ E Foley, J Glasgow, C Liston, Y Zheng, YL Huang, J Du. X Wang, N Cossrow, J Cai, D Wang2 Optimizing Systematic Literature Reviews in Endometrial Cancer: Leveraging AI for Real-Time Article Screening and Data Extraction in Clinical Trials Value in Health Volume 27, Issue 6, Supplement S279 June 2024
Datta S, Lee K, Paek H, Manion F, Ofoegbu N, Du J, et al. AutoCriteria: a generalizable clinical trial eligibility criteria extraction system powered by large language models. J Am Med Inform Assoc. 2024;31(2):375–385.
Lee K, Liu Z, Huang Q, Corrigan D, Kalsekar I, Jun T, et al. Decoding recurrence in early-stage and locoregionally advanced non–small cell lung cancer: insights from electronic health records and natural language processing. JCO Clin Cancer Inform. 2025;9:e2400227. doi:10.1200/CCI-24-00227.
Paek H, Fortinsky RH, Lee K, Huang LC, Maghaydah YS, Kuchel GA, Wang X. Real-world insights into dementia diagnosis trajectory and clinical practice patterns unveiled by natural language processing: development and usability study. JMIR Aging. 2025;8:e65221. doi:10.2196/65221.
Lee K, Paek H, Huang LC, Hilton CB, Datta S, Higashi J, et al. SEETrials: leveraging large language models for safety and efficacy extraction in oncology clinical trials. Inform Med Unlocked. 2024;50:101589. doi:10.1016/j.imu.2024.101589.
Lee K, Liu Z, Ma M, Mai Y, Li M, Gilman C, Zhang M, Wang T, Wang X. Empowering clinical trials with natural language processing models and real-world data: a feasibility study to optimize clinical trial eligibility design with data-driven simulations. JMIR AI. 2024.
Du X, Novoa-Laurentiev J, Plasek JM, Chuang YW, Wang L, Marshall GA, Mueller SK, Chang F, Datta S, Paek H, Lin B, Wei Q, Wang X, Wang J, Ding H, Manion FJ, Du J, Bates DW, Zhou L. Enhancing early detection of cognitive decline in the elderly: a comparative study utilizing large language models in clinical notes. EBioMedicine. 2024 Nov;109:105401. doi: 10.1016/j.ebiom.2024.105401. Epub 2024 Oct 12. PMID: 39396423; PMCID: PMC11663780.
Lee K, Liu Z, Chandran U, Kalsekar I, Laxmanan B, Higashi MK, et al. Detecting ground glass opacity features in patients with lung cancer: automated extraction and longitudinal analysis via deep learning–based natural language processing. JMIR AI. 2023;2:e44537.
Dave AD, Ruano G, Kost J, Wang X. Automated extraction of pain symptoms: a natural language approach using electronic health records. Pain Physician. 2022;25(2):E245–E254.
Ai L, Higashi M, Lee K, Liu Z, Jin L, Raja K, Wang X. Treatment sequencing patterns and comparative efficacy in patients with rheumatoid arthritis from a real-world setting. Ann Rheum Dis. 2022;81:1241.
Jin L, Ai L, Lee K, Liu Z, Raja K, Cohn D, Wang X. Treatment patterns and healthcare-resource utilization among chronic rhinosinusitis with nasal polyps patients in the new era of biologics. Value Health. 2022:S486.
Holmes AN, Swede H, Feer WM, Pike DC, Wang X, Hegde UP. Association of advanced age and cancer history with autoimmune disease in melanoma patients. BMC Cancer. 2021;21:1300. doi:10.1186/s12885-021-09001-1.
Hoag JR, Andemariam B, Wang X, Gregorio DI, Jones BA, Sporn J, Salner AL, Swede H. Serious adverse events in African-American cancer patients with sickle cell trait and inherited haemoglobinopathies in a SEER-Medicare cohort. Br J Cancer. 2019;120(8):861–863. doi:10.1038/s41416-019-0416-7.
Cook MJ, Yao L, Wang X. Facilitating accurate health provider directories using natural language processing. BMC Med Inform Decis Mak. 2019;19:78. doi:10.1186/s12911-019-0788-x.
Ru B, Wang X, Yao L. Evaluation of the informatician perspective: determining types of research papers preferred by clinicians. BMC Med Inform Decis Mak. 2017;17:74.
Brunson JC, Wang X, Laubenbacher RC. Effects of research complexity and competition on the incidence and growth of coauthorship in biomedicine. PLoS One. 2017;12(3):e0173444.
Wang X, Wei X, Agresta T, Smith M, Xu H. Mining clinical features in the diffusion and receipt of bevacizumab using electronic health records. AMIA Annu Symp Proc. 2013.
Demurjian S, De la Rosa Algarín A, Bi J, Berhe S, Agresta T, Blechner M, Wang X. Security for digital health care in the United States: what’s there? what works? what’s needed? Int J Privacy Health Inf Manag. 2014.
Wang X, Chase H, Markatou M, Hripcsak G, Friedman C. Selecting information in electronic health records for knowledge acquisition. J Biomed Inform. 2010;43(4):595–601.
Wang X, Hripcsak G, Friedman C. Characterizing environmental and phenotypic associations using information theory and electronic health records. BMC Bioinformatics. 2009;10(Suppl 9):S13.
Wang X, Hripcsak G, Markatou M, Friedman C. Active computerized pharmacovigilance using natural language processing, statistics, and electronic health records: a feasibility study. J Am Med Inform Assoc. 2009;16(3):328–337.
Wang X, Hershman DL, Abrams JA, Feingold D, Grann VR, Jacobson JS, Neugut AI. Predictors of survival after hepatic resection among patients with colorectal liver metastasis. Br J Cancer. 2007;97(12):1606–1612.
Hershman DL, Wang X, McBride R, Jacobson JS, Grann VR, Neugut AI. Delay of adjuvant chemotherapy initiation following breast cancer surgery among elderly women. Breast Cancer Res Treat. 2006;99(3):313–321.
Hershman DL, Wang X, McBride R, Jacobson JS, Grann VR, Neugut AI. Duration of adjuvant chemotherapy for colon cancer and survival among the elderly. J Clin Oncol. 2006;24(15):2368–2375.
Wang X, Quek H, Cantor M, Kra P, Schultz A, Lussier YA. Automating terminological networks to link heterogeneous biomedical databases. Stud Health Technol Inform. 2004;107(Pt 1):555–559.
Sollars V, Lu X, Xiao L, Wang X, Ruden DM. The role of Hsp90 in morphological evolution as a capacitor for epigenetic variation. Nat Genet. 2003;33(1):70–74.
Parr J, Large A, Wang X, Fowler S, Ruden DM. The inebi-actometer: a device for measuring the locomotor activity of Drosophila exposed to ethanol vapor. J Neurosci Methods. 2001;33(2):53–64.
Ruden DM, Sollars V, Wang X, Mori D, Alterman M. Membrane fusion proteins are required for oskar mRNA localization in the Drosophila egg chamber. Dev Biol. 2000;218:314–325.
Biography
- Over 16 years’ experience in Top 10 global pharma companies and data science company in HEOR, RWE, clinical development, and market access globally
- 40+ publications in high tier journals in clinical development, epidemiology, real-world study, and health economic modeling
- Experts in real-world evidence generation in support of strategic decision making, clinical development, regulatory submission, reimbursement negotiation, life cycle management, and medical communication; health economics modelling and value dossier generation and adaptations in major markets; innovative approaches and AI technologies to healthcare research, policy, and analytics
Selected Publications
Zhang, C., Ding, H., Li, J., Ramey, D. R., Zhu, B., Zhou, Z., Yang, M., & Lautsch, D. Epidemiology, disease burden of pulmonary arterial hypertension in China: A systematic literature review. Respiratory medicine, (2025)
Wang, Y; Cui, Y; Li, Y; Hu, B; Long, X; Xie, Q; Robinson, N; Zu, Y; Sun, N; Qian, X; Yang, M; He, S; Wei, S; Niu, Y; Risk for seizure in patients with prostate cancer treated with enzalutamide in China: A non-interventional study Therapeutic Advances in Drug Safety (2025)
Li, J., Liu, L., Cao, H., Yang, M., Sun, X. Use of real-world evidence to support regulatory decisions on medical devices in China and a unique opportunity to gain accelerated approval in “Boao Lecheng Pilot Zone”. Cost Effectiveness and Resource Allocation (2023)
J Januzzi, X Tan, L Yang, J Brady, M Yang, P Banka, D Lautsch N-terminal pro-B-type natriuretic peptide testing patterns in patients with heart failure with reduced ejection fraction. ESC Heart Fail (2022)
R Mentz, D Lautsch, Z Pulungan, S Kim, R Hilkert, C Teigland, M Yang, L Djatche Medication Trajectory and Treatment Patterns in Medicare Patients With Heart Failure and Reduced Ejection Fraction. Journal of Cardiac Failure (2021)
Fendrick AM, Djatche L, Pulungan Z, Teigland C, Yang M, Lautsch D, Hilkert R, Mentz R. Out-of-pocket payments for part d covered medications by medicare fee-for-service beneficiaries with heart failure with reduced ejection fraction. Am Heart J. (2021)
Wang Z, Chen X, Tan X, Yang L, Kannapur K, Vincent JL, Kessler GN, Ru B, Yang M. Using Deep Learning to Identify High-Risk Patients with Heart Failure with Reduced Ejection Fraction. J Health Econ Outcomes Res. 2021
Dunbar SB, Tan X, Lautsch D, Yang M, Ricker B, Maculaitis MC, Nagle T, Clark LT, Hilkert R, Brady JE, Spertus JA. Patient-centered Outcomes in HFrEF Following a Worsening Heart Failure Event: A Survey Analysis. J Card Fail. (2021)
Butler J, Yang M, Sawhney B, Chakladar S, Yang L, Djatche LM. Treatment patterns and clinical outcomes among patients <65 years with a worsening heart failure event. Eur J Heart Fail. (2021)
Givertz MM, Yang M, Hess GP, Zhao B, Rai A, Butler J. Resource utilization and costs among patients with heart failure with reduced ejection fraction following a worsening heart failure event. ESC Heart Fail. (2021)
P Goyal, B Bose, R Masteron Creber, U Krishnan, M Yang, J Brady, J Pathak. Performance of Electronic Health Record Diagnosis Codes for Ambulatory Heart Failure Encounters. Journal of Cardiac Failure (2020)
J Butler, L M. Djatche, B Sawhney, S Chakladar, L Yang, J E. Brady, M Yang. Clinical and Economic Burden of Chronic Heart Failure and Reduced Ejection Fraction Following a Worsening Heart Failure Event. Advances in Therapy (2020)
Butler J, Yang M, Manzi MA, Hess GP, Patel MJ, Rhodes T, Givertz MM. Clinical Course of Patients with Worsening Heart Failure with Reduced Ejection Fraction. J Am Coll Cardiol. (2019)
J Marcus, K Lasch, Y Wan, M Yang, C Hsu and D Merante. An Assessment of Clinically Important Differences on the Worst Pain Severity Item of the Modified Brief Pain Inventory in Patients with Diabetic Peripheral Neuropathic Pain. Pain Research and Management. (2018)
Liu Y, Qian C, Yang M. Treatment Patterns Associated with ACR-Recommended Medications in the Management of Fibromyalgia in the United States. J Manag Care Spec Pharm. (2016)
Yang M, Qian C, Liu Y. Suboptimal Treatment of Diabetic Peripheral Neuropathic Pain in the United States. Pain Med. (2015)
Colombel JF, Rutgeerts PJ, Sandborn WJ, Yang M, Camez A, Pollack PF, Thakkar RB, Robinson AM, Chen N, Mulani PM, Chao J. Adalimumab induces deep remission in patients with Crohn's disease. Clin Gastroenterol Hepatol (2014)
Feagan BG, Sandborn WJ, Lazar A, Thakkar RB, Huang B, Reilly N, Chen N, Yang M, Skup M, Mulani P, Chao J. Adalimumab therapy is associated with reduced risk of hospitalization in patients with ulcerative colitis. Gastroenterology (2014)
Sandborn WJ, Colombel JF, Panés J, Castillo M, Robinson AM, Zhou Q, Yang M, Thakkar R. Exploring the use of adalimumab for patients with moderate Crohn's disease: subanalyses from induction and maintenance trials. J Crohns Colitis (2013)
W. J. Sandborn1, J.-F. Colombel, G. D'Haens, G. Van Assche, D. Wolf, M. Kron, A. Lazar, A. M. Robinson, M. Yang, J. D. Chao, R. Thakkar One-year maintenance outcomes among patients with moderately-to-severely active ulcerative colitis who responded to induction therapy with adalimumab: subgroup analyses from ULTRA 2. Alimentary Pharmacology & Therapeutics (2012)
Liu Y, Wu EQ, Bensimon AG, Fan CP, Bao Y, Ganguli A, Yang M, Cifaldi M, Mulani P. Cost Per Responder Associated with Biologic Therapies for Crohn's Disease, Psoriasis, and Rheumatoid Arthritis. Adv Ther (2012)
Louis E, Löfberg R, Reinisch W, Camez A, Yang M, Pollack PF, Chen N, Chao J, Mulani PM. Adalimumab improves patient-reported outcomes and reduces indirect costs in patients with moderate to severe Crohn's disease: Results from the CARE trial. J Crohns Colitis. (2012)
D A. Sussman, N Kubiliun, P M. Mulani, J Chao, C Gillis, M Yang, M Lu, M T. Abreu, Comparison of Medical Costs Among Patients Using Adalimumab and Infliximab: A Retrospective Study (COMPAIRS) Inflamm Bowel Dis (2012)
Yang M, Robinson MA, Pollack FP. When Meta-Analysis Misleads. Am J Gastroenterol (2011)
Binion DG, Louis E, Oldenburg B, Mulani PM, Bensimon AG, Yang M, Chao J. Effect of adalimumab on work productivity and indirect costs in moderate to severe Crohn’s disease: A meta-analysis. Can J Gastroenterol. (2011).
Loftus EV, Guerin A, Yu AP, Wu EQ, Yang M, Chao J, Mulani PM. Increased Risks of Developing Anxiety and Depression in Young Patients with Crohn’s Disease. Am J Gastroenterol. (2011)
Wise B, Niu J, Yang M, Lane N, Harvey W, Felson D, Hietpas J, Nevitt MC, Sharma L, Torner J, Lewis C, Zhang Y. Patterns of Compartment Involvement in Tibiofemoral Osteoarthritis in Men and Women and in Caucasians and African Americans. Arthritis Care & Research (2011)
Y Liu, M Yang, J Chao, PM Mulani. Greater refill adherence to adalimumab therapy for patients using specialty versus retail pharmacies. Advances in therapy (2010)
T Neog, MC Nevitt, M Yang, JR Curtis, J Torner, DT Felson. Consistency of knee pain: Correlates and association with function. Osteoarthritis and Cartilage (2010)
F Eckstein, M Yang, A Guermazi, FW Roemer, M Hudelmaier, K Picha, F Baribaud, W Wirth, DT Felso. Reference values and Z-scores for subregional femorotibial cartilage thickness – results from a large population-based sample (Framingham) and comparison with the non-exposed Osteoarthritis Initiative reference cohort. Osteoarthritis Cartilage (2010)
A Guermazi, D Hayashi, FW Roemer, J Niu, M Yang, JA Lynch, JC Torner, CE Lewis, B Sack, DT Felson, MC Nevitt. Cyst-like lesions of the knee joint and their relation to incident knee pain and development of radiographic osteoarthritis: The MOST study. Osteoarthritis Cartilage (2010)
WF Harvey, M Yang, TD Cooke, NA Segal, N Lane, CE Lewis, DT Felson, Association of Leg-Length Inequality With Knee Osteoarthritis: A Cohort Study. Annals of Internal Medicine (2010)
M Englund, A Guermazi, FW Roemer, M Yang, Y Zhang, MC Nevitt, JA Lynch, CE Lewis, J Torner, DT Felson. Meniscal pathology on MRI increases the risk for both incident and enlarging subchondral bone marrow lesions of the knee: the MOST Study. Annals of the rheumatic diseases (2010)
NA Segal, NA Glass, DT Felson, M Hurley, M Yang, M Nevitt, CE Lewis, JC Torner. The Effect of Quadriceps Strength and Proprioception on Risk for Knee Osteoarthritis. Medicine and science in sports and exercise (2010)
NA Segal, NA Glass, J Torner, M Yang, DT Felson, L Sharma, M Nevitt, CE Lewis. Quadriceps weakness predicts risk for knee joint space narrowing in women in the MOST cohort Osteoarthritis and Cartilage (2010)
EY Kissin, J Nishio, M Yang, M Backhaus, PV Balint, GA Bruyn, J Craig-Muller, MA D'Agostino, A Feoktistov, J Goyal, A Iagnocco, RW Ike, I Moller, E Naredo, C Pineda, WA Schmidt, N Swen, D Tabechian, RJ Wakefield, AF Wells, GS Kaeley. Self-directed learning of basic musculoskeletal ultrasound among rheumatologists in the United States. Arthritis care & research (2010)
S Reichenbach, M Yang, F Eckstein, J Niu, DJ Hunter, CE McLennan, A Guermazi, F Roemer, M Hudelmaier, P Aliabadi, D.T. Felson. Does cartilage volume or thickness distinguish knees with and without mild radiographic osteoarthritis? The Framingham Study. Annals of Rheumatic Disease (2009)
DT Felson, KDGross, MV Hurley, M Yang, J Niu, NE Lane, JC Torner, CE Lewis, MC Nevitt. The effects of impaired joint position sense on the development and progression of pain and structural damage in knee osteoarthritis. Arthritis Care & Research (2009)
FW Roemer, A Guermazi, Y Zhang, M Yang, JA Lynch, H Toepfer, DJ Hunter, M Strauswald, MD Crema, MD Marra, K Bohndorf. Hoffa’s Fat Pad: Evaluation on Unenhanced MR Images as a Measure of Patellofemoral Synovitis in Osteoarthritis. American Journal of Roentgenology (2009)
M Englund, A Guermazi, FW Roemer, P Aliabadi, M Yang, CE Lewis, J Torner, M Nevitt,, B Sack, DT Felson. Meniscal Tear in Knees Without Surgery and the Development of Radiographic Osteoarthritis Among Middle-Aged and Elderly Persons: The Multicenter Osteoarthritis Study. Arthritis and rheumatism (2009)
B Wise, S Demissie, LA Cupples, DT Felson, M Yang, AM Shearman, P Aliabadi, DJ Hunter. The relationship of estrogen receptor-alpha and -beta genes with osteoarthritis of the hand. The Journal of Rheumatology (2009)
DT Felson, MC Nevitt, M Yang, M Clancy, J Niu, JC Torner, CE Lewis, P Aliabadi, B Sack, C McCulloch, Y Zhang. A New Approach Yields High Rates of Radiographic Progression in Knee Osteoarthritis. The Journal of Rheumatology (2008)
NA Segal, W Harvey, DT Felson, M Yang, JC Torner, JR Curtis, MC Nevitt. Leg Length Inequality is Not Associated with Greater Trochanteric Pain Syndrome. Arthritis Research & Therapy (2008)
NA Segal, JC Torner, M Yang, JR Curtis, DT Felson, MC Nevitt. Muscle Mass Is More Strongly Related to Hip Bone Mineral Density Than Is Quadriceps Strength Or Activity Level In Adults Over Age 50. Journal of Clinical Densitometry (2008)